Cellular network in airways inflammation and remodelling
نویسندگان
چکیده
منابع مشابه
Inflammation and remodelling in the ageing airway.
WHAT WE NEED TO KNOW: What changes occur in atopic and non-atopic airway inflammation in asthma with increasing age? What is the relationship between wound healing and airway remodelling in older subjects? What is the response to anti-inflammatory therapy in older subjects? What is the basis of the "overlap syndrome" with chronic obstructive pulmonary disease in older people with asthma, in who...
متن کاملCholinergic Regulation of Airway Inflammation and Remodelling
Acetylcholine is the predominant parasympathetic neurotransmitter in the airways that regulates bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine regulates additional functions in the airways, including inflammation and remodelling during inflammatory airway diseases. Moreover, it has become apparent that acetylcholine is synthesized by nonneuronal cells and ti...
متن کاملAssessment of airways inflammation in chronic bronchitis.
Chronic bronchitis is a clinical syndrome, defined on the basis of sputum production [1, 2]. Investigations have demonstrated that airway inflammation is central to the clinical changes associated with chronic bronchitis. Histological investigations of surgical and autopsy specimens have provided material to determine the site and nature of the airway inflammation. Sampling of the airways via f...
متن کاملAirways inflammation and COPD: epithelial-neutrophil interactions.
Neutrophils are recognized as major cellular mediators of inflammation. They contain specific and highly regulated mechanisms for controlling the expression of adhesion molecules that allow for their tethering and migration into inflammatory sites. These adhesion molecules not only are activated by exogenous pollutants but are regulated by endothelial and epithelial cell signals. Lipid mediator...
متن کاملNovel concepts in airway inflammation and remodelling in asthma.
The hallmark pathological features of asthma include airway eosinophilic inflammation and structural changes (remodelling) which are associated with an irreversible loss in lung function that tracks from childhood to adulthood. In parallel with changes in function, pathological abnormalities occur early, during the pre-school years, are established by school age and subsequently remain (even th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Paediatric Respiratory Reviews
سال: 2002
ISSN: 1526-0542
DOI: 10.1053/prrv.2001.0166